| toxicity | rat acute oral ld50981 mg/kg (male), 1051mg/kg (female), mouse acute oral ld501299 mg/kg (male), 946mg/kg (female); Female, male rats acute percutaneous LD50>2000mg/kg; Female, acute inhalation LC50>3450mg/m3 in male rats. It has slight irritation to rabbit eyes and no irritation to rabbit skin. The skin of guinea pig had no sensitization. A large number of short-term and long-term toxicity tests showed that the compound had no mutagenic effect on bacteria, no teratogenic effect on rats and rabbits, and no harmful effect on pharmacological studies of rats, mice, rabbits and guinea pigs. Lithium fish lc5016.9 mg/L (48h), crucian carp lc5020.0 mg/L (48h), hard-headed trout lc504.0 mg/L (48h), Jian flea LC50>100mg/L (6h). Bee exposure ld50100 μg/only. Quail acute oral LD502380mg/kg, chicken acute oral LD504220mg/kg. |
| Use | imidazole fungicide. For rice seed treatment, the control of seed transmission of pathogenic fungi, especially in rice crops caused by Fusarium moniliforme in rice disease, the rice flax leaf spot caused by Rice blast caused by Rice and pear spore Spore and the uterine part of the fungus is very effective. At low concentration, the growth and development of species-borne pathogenic fungi can be prevented by blocking the biosynthesis of ergosterol and inhibiting the growth of germination tubes and strains. Fusarium moniliforme is effective against Benzimidazole fungicides. In the seedling box, the test showed that with 20% wettable powder 200~400 times of liquid soaking for 24h, or 20~40 times of liquid soaking for 10min, or with 0.5% of the dry weight of the seed wet coating, all patients received good control effect. |
| production method | 10g(0.033mmol) of N-1-(1-pent-4-allyloxypropyl)-N-furfuryl carbamoyl chloride is dissolved in 100ml DMF solution, 10g (0.15mol/L) of imidazole and 5g of potassium carbonate are added, reaction is carried out at 70 ℃ for 1H, water is added at the end of reaction, toluene is extracted, organic layer is concentrated, the residue was recrystallized from a toluene-n-hexane mixed solvent. |
![2-[Furfuryl(1H-imidazole-1-ylcarbonyl)amino]butanoic acid 4-pentenyl ester](http://res.chembk.com/assets/str/2d/1/10/101903-30-4.png)